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Welcome to Gut-Research

Wouter de Jonge's research group:
Gut-Research

At the forefront of gastrointestinal research, Wouter de Jonge's group dives into the underlying mechanisms of functional and inflammatory bowel diseases. Their work spans four key areas: intestinal microbiota, personalized treatment for Inflammatory Bowel Disease, innovative colorectal cancer care, and enhancing newborn gut health.

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Welcome to Gut-Research

Intestinal microbiota and health

We explore the intricate relationship between the microbiota and human health, focusing on gut diseases. Our research group at the Microbiota Center Amsterdam aims to uncover new treatments that promote a healthy gut ecosystem by analyzing microbial influence on immunity and well-being.

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Welcome to Gut-Research

Inflammatory Bowel Disease and personalized medicine, microbiome and nutrition

Our research lab focuses on the pathogenesis and personalized treatment of Inflammatory Bowel Diseases (IBD). Using advanced techniques like single-cell sequencing and Mass Cytometry, we translate clinical research into innovative therapeutic approaches.

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Welcome to gut-research

Colorectal cancer treatment and post-operative care for cancer patients

We investigate the challenges of surgical healing, particularly anastomotic leakage in colorectal surgery. Our preclinical and clinical research aims to improve outcomes by understanding the cellular processes involved in wound healing and tissue regeneration.

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Welcome to gut-research

Intestinal health for newborn

We study how early nutrition, particularly breast milk, protects newborns from infections and long-term health risks like obesity and diabetes. Our research group focuses on understanding the mechanisms that support neonatal gut health, giving infants the best start in life.

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WHO WE ARE

Explore Our Cutting-Edge Gut Health Research Areas

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We study the complex interactions between the microbiota and the human body in the context of human intestinal disease, in collaboration with Micrbiota Center Amsterdam facilities. Our research focuses on how these microorganisms influence gut health, immunity, and overall well-being. By studying the microbiome's role in diseases such as inflammatory bowel disease and cancer, we aim to develop innovative treatments that restore and maintain a healthy gut ecosystem.

We have co-founded the Amsterdam Microbiome Center (see here); analysing how microbiome research host interactions that affect gut epithelial barriers and immunity,.

Pathogenesis and personalised treatment of Inflammatory Bowel Diseases (IBD), utilizing translational research and clinical trial analyses, including advanced techniques like single-cell sequencing and Mass Cytometry.

Preclinical and clinical research in surgical complications, wound healing, and anastomotic healing. Anastomotic leakage (AL) is a dreaded complication after colorectal surgery. Unravelling the early processes underlying anastomotic healing (AH) is crucial to understand the pathophysiology of AL and thereby reduce the high morbidity and mortality rates. Our aim is to understand wound healing and its morphological, cellular and intrinsic molecular changes in the anastomotic tissue.

Early life nutrition to prevent disease: Breast milk protects newborns from infections and reduces obesity and diabetes risks later in life. When breastfeeding isn't possible, infant formula is recommended, though it lacks breast milk's protective effects. Understanding these benefits is crucial, especially for vulnerable neonates and preterm infants. We study these mechanisms to improve infant health.

What we offer

Advancing Gut Health Through Innovation and Collaboration

At Gut-Research, we are committed to advancing the understanding and treatment of gastrointestinal diseases through innovative research and state-of-the-art technology. Our team of experts provides comprehensive services and cutting-edge solutions to address the challenges in gut health. Explore the wide range of offerings that make us a leader in the field.

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Advanced Research Facilities

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Collaborative Projects

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Clinical Trials and Studies

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the team

our experienced scientists

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Wouter de Jonge

Group Leader - Prof, PhD
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Rene van den Wijngaard

Ass. Prof,
PhD (IBS Research)
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Anje A. te Velde

Ass. prof,
PhD (Principal Investigator)
Ongoing projects

See our current ongoing projects

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Andrew Li Yim

IBD Methylomic and OMICROHN Trial

Led by Andrew Li Yim, the IBD Methylomic and OMICROHN Trial aims to uncover the epigenetic factors influencing inflammatory bowel disease (IBD). By analyzing methylomic changes, this project seeks to provide new insights into IBD progression and potential personalized treatments.

Methylomic
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Mohammed Ghiboub

Biomarker Development and Epigenetics in Gut Inflammation

This project focuses on the development of biomarkers and understanding the epigenetic mechanisms that drive cell differentiation during gut inflammation. By studying these processes, the research aims to improve diagnostics and therapeutic strategies for inflammatory gut diseases.

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Isabelle van Thiel

Complications in Crohn's Disease: Fistulae Research

Led by Isabelle van Thiel, this project focuses on identifying biomarker profiles to predict treatment responses in patients with perianal fistulizing Crohn's disease. By developing a precision medicine approach, the research aims to improve treatment outcomes and quality of life for those affected by this severe complication

Project details
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Gut-research

Gut-Brain Interactions and Neuroinflammation in GI Diseases

This research examines the complex interactions between the gut and brain, focusing on neuroinflammation in conditions such as IBD, Irritable Bowel Syndrome (IBS), and motility disorders. In collaboration with Galvani Bioelectronics, this project aims to deepen our understanding of these interactions to improve treatments.

Galvani
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Rene van den Wijngaard

METARYL 2023-2027

Metaryl is an EU JPI funded project that aims to study how the nutritional component tryptophane affect wound healing and infection in diabetes First, we study how tryptophan metabolites affect the development of wound infections Second we determine how inflammation of the fat tissue in the abdomen plays a role in the development of type2 diabetes. Third we will test dietary interventions in this process, to help people cope with this problem. METARYL partners with professor Sven Wehner, University of Bonn, and Harry Sokol from Sorbonne University in Paris, France.

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Gut-research

Anastomotic leakage (AL)

Anastomotic leakage (AL) is a serious complication following colorectal surgery. This study aims to assess AL by investigating the morphological, cellular, and molecular changes in anastomotic tissue, with the goal of improving patient outcomes. Supported by ZonMW.

ZonMW
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Bruno Sovran

Micropial: Wound Healing and Probiotics

Led by Bruno Sovran, the MICROPIAL project investigates how probiotics influence wound healing and anastomosis following cancer surgery. Funded by Health Holland and MRM Health, this research aims to advance understanding of probiotic therapies in surgical recovery. Learn more at Health Holland and MRM Health.

Health Holland
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Gut-research

Intercept

INTERCEPT, funded by the EU Horizon Europe programme, aims to validate a biomarker panel to identify individuals at high risk of developing Crohn’s Disease, allowing for early interception. Despite earlier diagnoses, many Crohn’s patients still face severe bowel damage and increasing disability. By detecting the disease at a pre-clinical stage, this project hopes to improve management and outcomes. With 52 partners and a budget of 37 million euros over six years, INTERCEPT seeks to transform how Crohn's Disease is diagnosed and treated.

Intercept
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GROWTH 2020-2024

Metaryl is an EU JPI funded project that aims to study how the nutritional component tryptophane affect wound healing and infection in diabetes First, we study how tryptophan metabolites affect the development of wound infections Second we determine how inflammation of the fat tissue in the abdomen plays a role in the development of type2 diabetes. The GROWTH program, part of the European Industrial Doctorates (EID), involves 10 PhD students developing biomarkers and personalized nutritional interventions for intestinal failure in neonates and preterm infants. By working with both academic and non-academic partners, the program bridges the gap between research and clinical applications. Utilizing over 17,000 fecal samples from premature infants, GROWTH aims to improve early intestinal development and reduce neonatal health risks.

Growth EID
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At Gut-Research, your health and well-being are our top priorities. Our dedicated team of experts is ready to provide you with the best care and support in gastrointestinal health. Whether you are a patient, a researcher, or a healthcare professional, we are here to assist you.

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Recent news

Gut-research Recent Publications

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Written by:
Wouter de Jonge sep 17, 2024

INTERCEPT: Pioneering Early Detection for Crohn’s Disease

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